Osteoporosis Induced by Medicines

Certain medications that are essential for managing other medical conditions can negatively impact bone health, increasing the risk of osteoporosis and fractures.

Certain medications essential for treating other conditions can weaken bones. Monitoring and proactive management are crucial to reducing the risk of fragility fracture.

Glucocorticoids, commonly prescribed for inflammatory conditions like rheumatoid arthritis, are a significant cause of secondary osteoporosis. Prolonged use of these medications can lead to substantial bone loss and increased fracture risk.

Similarly, Androgen Deprivation Therapy (ADT), a mainstay treatment for prostate cancer, reduces testosterone levels, leading to bone density reduction and higher fracture rates. Aromatase inhibitors (AIs), used in hormone receptor-positive breast cancer treatment, also contribute to decreased bone density.

Healthcare professionals should be vigilant in monitoring bone health in patients undergoing these treatments. It is essential to conduct bone density scans and assess fracture risk using tools such as FRAX® or the Garvan Fracture Risk Calculator.

Proactive management, including prescribing osteoporosis-specific medications and advising on lifestyle modifications, can mitigate the adverse effects on bone health. Discussing these potential risks with patients ensures they are informed and can take steps to protect their bone health.