Osteoporosis-specific Medications

If you have been diagnosed with osteoporosis, your healthcare provider will recommend the most suitable medication for you. Several medications can strengthen bones and reduce the risk of fractures by 30% to 70%. These include bisphosphonates, denosumab, teriparatide, hormone replacement therapy (HRT), and raloxifene.

Starting the right treatment can help prevent future fractures and protect your bones.

Bisphosphonates are the most widely used treatments. They work by binding to the bone surface and making cells that break down bone (osteoclasts) less active. This reduces bone resorption, while cells that build bone (osteoblasts) remain active, continuing to form new bone. Bisphosphonates are available in daily or weekly tablets, such as alendronate and risedronate, or as an intravenous infusion of zoledronic acid.

Denosumab is given as an injection under the skin every six months. It works by blocking a protein that activates osteoclasts, thus reducing bone breakdown. It is important to have the injection every six months because the effects of the medication wear off very quickly.

Teriparatide is a type of parathyroid hormone that leads to new bone formation by stimulating osteoblasts. It is usually given as a daily injection for up to 18 months, making it a very good option for severe cases of osteoporosis.

Hormone Replacement Therapy (HRT) is especially beneficial for postmenopausal women. HRT helps maintain bone density by replacing oestrogen, a hormone that decreases after menopause and contributes to bone loss.

Raloxifene is another medication for treating osteoporosis in postmenopausal women. Raloxifene acts like oestrogen in some parts of the body, such as the bones, and has been proven to reduce the risk of vertebral fractures. In other areas, like the breasts and uterus, it blocks the effects of oestrogen.

Each of these medications has been rigorously tested and proven to be safe and effective. Your healthcare provider will discuss the best option based on your health history, risk factors, and personal preferences, ensuring a treatment plan tailored to your needs.